The Senior Day showdown will tip at 4:30 p.m. and can be seen on Fox Sports Net.
Before the contest, MSU will honor senior guard Baxter Price. The Brandon, Miss., native has logged 90 minutes this season after playing just 29 minutes in his first three seasons combined.
"I'm so proud of Baxter," MSU coach Rick Ray said. "He's bought in to our program and has done everything we have asked of him. He's an unselfish player who has a bright future in whatever he chooses to do."
Mississippi State (8-21, 3-14) hopes to replicate the home success it found in a 73-67 victory against archrival Ole Miss last weekend. The Maroon and White dropped a 79-72 decision in midweek action at South Carolina.
AU (9-21, 3-14) fell 82-75 to Tennessee on Wednesday. The Tigers enter Saturday's matchup on an eight-game losing skid and have only won two games away from Auburn Arena all season.
Last season, the Bulldogs defeated Auburn 91-88 in Starkville before falling 65-55 on The Plains.
MSU holds a 40-25 series advantage at home. Raucous crowds at The Hump have proven a huge asset in recent years, as Mississippi State has won 11 of the previous 12 home games against the Tigers.
Before suffering a season-ending knee injury on Wednesday, junior Jalen Steele led the Bulldogs in scoring with 10.1 points per game. Freshman Craig Sword averages double-figures for the Bulldogs with 10.0 points an outing.
Frankie Sullivan paces AU with a 14.5 scoring clip. Chris Denson (11.1 points) and Rob Chubb (8.7) also serve key roles in the Auburn scoring attack.
Following the regular season finale, Mississippi State will head to Nashville for SEC Tournament play beginning Wednesday.
A win on Saturday would ensure that MSU plays South Carolina at 6:30 p.m., while a loss to Auburn would mean that the Bulldogs play either Texas A&M or Vanderbilt at 9 p.m.
Wednesday's postseason lid-lifter will be televised by the SEC Network.