Fox Sports South will have the telecast, with Dave Neal handling the play-by-play duties and Larry Conley serving as the color commentator.
The Bulldogs (7-20, 2-13) look to snap a 13-game losing skid after falling 85-55 at Kentucky on Wednesday, where Fred Thomas paced MSU with 13 points.
Coach Andy Kennedy's Rebels (21-7, 10-5) invade Starkville after holding off Texas A&M in its last outing, 82-73.
The two squads met in Oxford on Feb. 6, with UM claiming a 93-75 win. Craig Sword netted an impressive 17 points to lead the Maroon and White.
Mississippi State has dominated the all-time series in Starkville, holding a 91-24 advantage. The Bulldogs have won 17 of the last 19 meetings with their archrivals at The Hump.
Ole Miss has not swept the season series with MSU since 1998. The Maroon and White have swept the Rebels on six different occasions in that time span.
Sword (9.8 points) and Jalen Steele (9.7) lead the Bulldogs in the scoring column. Marshall Henderson leads the Rebels and the Southeastern Conference with 19.6 points per game. UM averages a league-best 79.2 points as a team.
Following Saturday's rivalry showdown, Mississippi State will travel to South Carolina on Wednesday for its final road game of the season. The 6 p.m. tilt in the Palmetto State can be seen online at ESPN3.com.