The SEC Network will televise the 7 p.m. clash at Rupp Arena, with Dave Neal and Jon Sundvold providing courtside commentary for the matchup.
MSU (7-19, 2-12) fell 72-31 to Vanderbilt at Humphrey Coliseum on Saturday, while the Wildcats (19-8, 10-4) defeated Missouri 90-83 on Saturday in overtime, Julius Mays drained four treys en route to 24 points as UK rallied to win its second-straight outing.
Last season, the Maroon and White built a 13-point halftime lead against the top-ranked Wildcats, but Kentucky would fight back to earn the 73-64 comeback victory in Starkville.
Three of the past seven matchups in the series have been settled in overtime. The last five meetings have been decided by an average of 6.2 points.
"For me, personally, I'm looking forward to playing at Rupp Arena," MSU coach Rick Ray said. "I'm a college basketball fan, so, I'm excited about bringing a team to Rupp. What we're trying to do is find the weaknesses Kentucky has and try to exploit them. Now are we good enough to exploit them? For some it would be yes and some of them no."
Freshmen play a huge role for both squads. The trio of Craig Sword, Fred Thomas and Gavin Ware average a combined 28 points for Mississippi State, while freshmen lead UK in almost every statistical category.
Sword paces MSU with 9.8 points per game, while Ware leads the Bulldogs on the boards with 6.5 rebounds.
Archie Goodwin leads the Wildcat scoring attack with 13.9 points a game and averages a team-best 3.1 assists.
After Wednesday's clash, Mississippi State prepares for another intense showdown as it hosts archrival Ole Miss this Saturday. The 4 p.m. tilt will be televised by Fox Sports Net.