The SEC Network will televise the 7 p.m. matchup at Coleman Coliseum. Dave Neal and Jon Sundvold will provide courtside commentary.
Coach Rick Ray's squad looks to bounce back after an 80-68 loss in Baton Rouge on Saturday. The Bulldogs (7-17, 2-10) are searching for their first league win since beating Georgia 72-61 on Jan. 12.
Alabama (17-8, 9-3) enters the contest on a three-game winning streak and currently sits in second place in the conference standings. The Crimson Tide knocked off South Carolina 68-58 on Saturday.
In January, Bama defeated MSU 75-43 at Humphrey Coliseum, giving the Maroon and White its first SEC loss of the season.
"The one thing that is really good about Alabama is they have guys who are versatile," Ray said. "With Rodney Cooper and Devonta Pollard, both of those guys are inside-outside players, and you've got guys like (Trevor) Releford and Trevor (Lacy) who can handle the basketball and also make shots."
Coming off a career-high 25 points against LSU, freshman guard Craig Sword paces Mississippi State with 10.2 points a game. Junior college transfer Colin Borchert leads the team in blocked shots with 1.4 per outing. Borchert swatted three Tiger shots to go along with his 11 points and four steals in Baton Rouge.
Point guard Trevor Releford leads the Tide in scoring with 14.4 points and also shoots a team-best 46.5 percent from the field. Releford missed the first matchup with MSU due to an injury.
After Wednesday's road trip, the Bulldogs will play three of their final five regular season games in the friendly confines of Humphrey Coliseum. The Vanderbilt Commodores travel to The Hump on Saturday for a 12:30 p.m. matchup on the SEC Network.