CSS will televise the 8 p.m. tilt, with Mike Morgan and Daymeon Fishback serving as courtside broadcasters.
Both teams enter the contest on four-game losing streaks after winning their first two conference games. The Bulldogs (7-11, 2-4) fell 82-47 to Florida on Saturday, while the Aggies (12-7, 2-4) dropped a 59-52 decision to Georgia at home.
Hopefully our guys have learned from the Florida game," MSU coach Rick Ray said. "It's an important week for us with a two-game homestand, and trying to get our guys to understand where we are in the SEC. With seven teams being at 2-4, if they can make some hay here at home, we're right back in the conference race and trying to be in the upper division of the conference, which I think is important."
Wednesday's meeting will be only the fourth all-time between the schools and the first as Southeastern Conference foes. MSU currently leads the series 2-1 after a 69-60 victory last season in New York at the 2K Sports Classic. Texas A&M's lone win came in 1964.
The Bulldogs have never played a home game against the visitors from College Station, as all previous matchups in the series have been held at a neutral sites.
After a career-high 19-point performance against Florida, freshman guard Fred Thomas has taken the lead for Mississippi State in the scoring column with an average of 11.1 points per outing. The Bulldogs rank fifth in the SEC in steals, as Thomas and fellow freshman Craig Sword both average a squad-best 1.9 steals a game.
Senior guard Elston Turner leads the Aggie scoring attack with 15.7 points per contest, and he has shown explosive offensive potential. The former Washington transfer netted 40 points in a huge win at Kentucky earlier this month.
Following Wednesday's showdown, Mississippi State closes out a three-game home stand on Saturday as the LSU Tigers visit Humphrey Coliseum. Tip-off is set for 4:30 p.m., and Fox Sports Net will provide the game's telecast.