Tip-off is set for 7 p.m. at Humphrey Coliseum, with Dave Lamont and Kara Lawson handling play-by-play and color commentary for the ESPN2 broadcast.
The Bulldogs (7-10, 2-3) enter the contest looking to bounce back from a 96-70 setback at Arkansas. The Gators (15-2, 5-0) find themselves first in the SEC standings after defeating Georgia on Wednesday, 64-47.
Six of the previous seven meetings in the series have been decided by single digits, with Mississippi State winning four of those matchups. UF gained the upper hand in last season's clash of ranked teams with a 69-57 win in Gainesville.
The Bulldogs currently hold a 34-20 home record against the Gators, including two straight victories in Starkville.
Roquez Johnson paces MSU in scoring with 10.7 points per outing. Following an impressive 17-point performance at Arkansas, freshman Fred Thomas ranks second on the team in scoring with 10.6 points a game.
Florida ranks third in the nation in scoring defense, allowing only 51.4 points per game. Kenny Boynton (13.3 points) and Erik Murphy (12.5 points) lead the Gator attack on the offensive end.
For the first time league expansion in 1992, the teams will play twice in the regular season. Mississippi State makes to return trip to Gainesville on Feb. 9.
The Bulldogs continue their three-game home stretch on Wednesday against SEC newcomer Texas A&M at Humphrey Coliseum. CSS will televise the 8 p.m. tilt.